A NEW CLASS OF BIOSYNTHETIC ANTHRACYCLINES : ANTHRACYCLI NO NE GLUCURONIDES Sir: Our previous search for new anthracyclines
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چکیده
produced by mutants of Streptomyces peucetius^ , the daunorubicin2) producing microorganism, led to the discovery of doxorubicin (adriamycin)3) and other new anthracyclines4~8). By further mutagenic treatment of Streptomyces peucetius var. aureus, sl mutant of Streptomyces peucetius producing 4Odemethyl1 1 deoxydoxorubicin and analogues7), we have recently isolated other new mutant strains. Amongthem, two mutants designed Streptomyces peucetius var. vinaceus (NRRL 15344) and Streptomyces peucetius var. castaneus (NRRL15345), were found to produce respectively 40-(/3-D-glucopyranuronosyl)-s-rhodomycinone (1)9) and 4-O-(/3'-D-glucopyranu-
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